Asuragen’s Clinical Laboratory Launches KRAS And BRAF Mutation Testing
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Also Included In: Cancer / Oncology ; Medical Devices / Diagnostics
Asuragen, Inc., a leader in molecular nosology and nucleic acid-based pharmacogenomics services, proclaimed that it has launched KRAS and BRAF mutational examination services in its CAP-accredited CLIA lab. Asuragen’s KRAS and BRAF lab highly-developed tests (LDTs) were intentional in reply to new limited guidelines from the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN). Asuragen’s KRAS and BRAF tests are intended to be victimised and taken in connective with all early useable clinical and symptomatic entropy when evaluating anti-EGFR discourse options for colorectal cancer (CRC) patients. The tests are useable in diverse configurations based on the patient’s demand or the clinical tribulation aim. The KRAS 7 Mutation examination serving allows for sleuthing of the 7 clinically relevant KRAS mutations in codons 12 and 13 and the KRAS 12 Mutation essay constellation expands the KRAS 7 quiz to observe an extra fin KRAS mutations in codon 13.
“Adding KRAS and BRAF mutational examination to our CLIA lab card encourage expands our delegacy in delivery individualized music solutions to our partners and patients,” aforementioned Carol Berry, Vice President and General Manager of Asuragen’s Pharmacogenomics Services. “In summation, our CLIA lab provides our pharmaceutic and biotechnology partners with the entire accompaniment of attempt evolution services and regulated examination facilities.”
RAS genes are the well-nigh commons targets for bodily gain-of-function mutations in humming cancers . Activating RAS mutations happen in about 30% of thrum cancers and particular RAS genes are mutated in unlike cancers, including colorectal cancer (CRC), non-small cellphone lung cancer , pancreatic cancer and others. Some mutations in the KRAS cistron (roughly 40% of colorectal cancer patients) are associated with hapless prospect and deficiency of answer to anti-EGFR therapy. In July 2009, the FDA sanctioned labeling changes to cetuximab and panitumumab stating that these agents are not recommended for the discourse of colorectal cancer (CRC) harboring KRAS mutations. Thus, conclusion of KRAS sport position in these tumors is vital when evaluating a patient for anti-epidermal ontogenesis element receptor therapy. ASCO has encourage recommended that all patients with metastatic colorectal cancer for whom EGFR antagonists are beingness considered should be specifically tried for KRAS mutational position at codons 12 and 13.
BRAF is a downriver particle from KRAS in a sign tract tangled in cubicle cycling, and care KRAS, mutations in BRAF are ascertained in CRC. Data from the CRYSTAL run suggests that BRAF mutations are besides indicatory of hapless forecast and the NCCN Colon Cancer Guideline Update 2010 states that examination for mutations in BRAF (identified in 3% to 12% of CRC patients) should pass when KRAS examination indicates KRAS barbaric typecast.
Source:
Asuragen, Inc.
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